Rose Hathaway is a Dhampir, which is a hybrid species of half-vampire and half-human. She is training with her mentor, Dimitri Belikov, to become a guardian for Lissa Dragomir, a member of the royal Moroi vampire family. Lissa and Rose are best friends, and Lissa possesses a rare ability to heal others, which makes her a target for those who wish to exploit her powers.
After running away from the academy, Rose and Lissa are captured and returned to St. Vladimir's Academy, where they encounter hostility from some students and guardians who believe they are a danger to the academy. Meanwhile, Rose begins to develop romantic feelings for Dimitri, which complicates their professional relationship.
As they navigate their way through school, Rose discovers a plot by members of the Moroi royal family to control Lissa and use her for their own gain. With the help of Dimitri and a few other friends, Rose must protect Lissa from those who would harm her and uncover the truth behind the sinister plot.
However, their efforts are complicated by the presence of the Strigoi, a group of evil vampires who threaten the safety of the academy and its inhabitants. As the Strigoi close in on their target, Rose must use all her training and skill to protect her friend and defeat the enemy.
The film, based on the best-selling book series by Richelle Mead, blends action, romance, and supernatural elements into a thrilling and entertaining ride through the world of vampires.