The strange things brewing in New York City are the emergence of a powerful villain named Max Winters who has enlisted the help of ancient monsters to aid him in his quest for domination. Winters is a wealthy businessman who has been alive for centuries due to his association with a powerful amulet.
The Turtles, who have been living separate lives, are brought back together by April O'Neil, their former ally and friend. However, their reunion is not without tension and conflict as they struggle to trust each other again.
As they investigate Winters and his army of monsters, the Turtles realize that their old enemy, The Foot Clan, has also returned and is in league with Winters. The Turtles also discover that Winters' amulet is closely tied to their own lineage and they must race against time to prevent its destruction.
In the end, the Turtles and their allies must work together to defeat Winters and his army and save New York City from destruction. Through their adventures, they rediscover their unity as a family and reaffirm their commitment to each other.