The Yellow Handkerchief follows the journey of three individuals – Brett Hanson, Martine and Gordy – who find themselves traveling together through rural Louisiana. Brett is a recently released convict who is struggling to reconnect with his estranged wife, May. Martine is a troubled teenager who is running away from home, and Gordy is a shy and awkward teenager who is desperate for attention.
As they drive through the beautiful landscapes of Louisiana, the three strangers begin to bond and open up to each other about their pasts and their hopes for the future. Martine reveals that she ran away from home because she was struggling with her sexuality, while Gordy confesses his fear of never being loved.
Brett, who is initially guarded and closed off, begins to let his guard down as he spends more time with Martine and Gordy. The trio gets into all sorts of trouble along the way, from being chased by an angry truck driver to spending a night in a haunted house.
As they journey through Louisiana, the three strangers discover that they are not as alone as they thought they were. Together, they find a sense of belonging and learn to embrace their vulnerabilities and weaknesses. By the end of their journey, they are forever transformed by the experiences they have shared and the connections they have made.