In Scooby-Doo! in Where's My Mummy?, the Mystery Inc. gang travels to Egypt to help archeologist and explorer Professor Alejo Otero with an important discovery. Otero has found the legendary lost tomb of Cleopatra, and he needs the gang's help to uncover its secrets. However, things take a mysterious turn when they discover that the tomb is being haunted by the vengeful spirit of the Ancient Egyptian queen herself.
As they navigate through ancient tombs and face-off with ongoing curses and mummies that come to life, the gang must use their wit and bravery to uncover the truth behind the curse of Cleopatra and save their own lives. Along the way, they also meet new allies, such as the eccentric tourist and Otero's assistant, Professor Amelia von Butch, and the handsome and daring Prince Omar.
As always, the gang's beloved canine, Scooby-Doo, and his best friend Shaggy bring comic relief and a sense of humor to the group's dangerous investigations. Will they be able to solve the mystery and uncover the secrets of Cleopatra's tomb, or will they fall victim to the curse themselves?