The two inept criminals, Leo and Guch, work as deliverymen for a shipping company in Philadelphia. While on the job, they come across a package containing ten bricks of cocaine, which was supposed to be delivered to a drug lord named Bodega.
Thinking they've struck it rich, Leo and Guch decide to sell the cocaine and make some quick cash. However, their plan soon goes awry when they accidentally deliver the package to the wrong address – the home of a couple named Jesus and Chita who are struggling to make ends meet.
Meanwhile, Bodega and his crew are on the hunt for the missing package and are willing to do whatever it takes to get it back. As the chaos unfolds, ten people's lives become intertwined in unexpected ways.
Next Day Air is a dark comedy that explores the consequences of greed and the unintended consequences of criminal activity. The film features an ensemble cast that includes Donald Faison, Mike Epps, Wood Harris, and Mos Def.