In Monster High 2, Clawdeen, Draculaura and Frankie are still navigating the complexities of high school life at Monster High. As they start their sophomore year, they meet a group of new students who have unique powers and abilities. Among them is Luna Moth, a shy and introverted girl with the power of flight, and Viperine Gorgon, a charismatic and confident snake-haired girl who can control hypnotic powers.
As Clawdeen, Draculaura, and Frankie get to know their new classmates, they also discover that their own powers are evolving, and they must learn to control them. But their new powers are also attracting the attention of a powerful and dangerous entity known as the Dark Queen, who seeks to use their powers for her own sinister purposes.
As they work to uncover the Dark Queen's true intentions, Clawdeen, Draculaura and Frankie find themselves in the middle of a high stakes battle that could change the course of Monster High history. Along the way, they must navigate shifting alliances, old rivalries, and their own personal struggles, all while staying true to themselves and their friendships.