Little Italy is a romantic comedy film that explores the love story of two childhood friends, Leo Campo (Hayden Christensen) and Nikki Angioli (Emma Roberts), who grew up in a charming Italian neighbourhood in Toronto. As adults, they both return to Little Italy, where they fall in love with each other, but their romantic relationship is threatened by their families' longstanding feud and rival pizzerias. The film features a clash between Leo's father, Carlo (Danny Aiello), who owns the family-owned pizzeria, and Nikki's mother, Dora (Alyssa Milano), who owns the rival pizzeria, which creates a situation of bitterness between the families for years.
The movie shows how Leo and Nikki navigate their way through their parents' longstanding hatred while trying to maintain their relationship amidst the battle between their families' pizzerias. They use their childhood friendship as a foundation to rekindle their romance despite the difficulties they face because of their families' rivalry.
As the love between Leo and Nikki blossoms, they work towards finding a way to bring their feuding parents together, so they can live happily ever after. The film showcases the power of love and how it can overcome even the most bitter of rivalries.