In Keith Robinson: Different Strokes, the comedian shares personal and humorous insights into his life, including anecdotes about his experiences trying to order food after suffering a stroke, as well as the awkwardness of taking Viagra on an airplane. The special also delves into Robinson's perspectives on aging, relationships, and the challenges of dealing with health issues. With his trademark wit and candor, Robinson offers a comedic take on life's ups and downs, delivering a stand-up performance that is both insightful and laugh-out-loud funny.