The group of friends consists of two couples and their single friend. They arrive in Panama and settle into their hotel, ready for a week of partying and exploring. At the hotel bar, they meet a local woman named Isla who offers to take them on a day trip to a beautiful waterfall in the jungle. Against the advice of Isla's brother Miguel, who warns them of dangerous creatures that inhabit the jungle, the Americans agree to go.
Upon arriving at the waterfall, the group decides to go for a swim. As they're splashing around, Isla suddenly disappears without a trace. The friends frantically search for her in the jungle but are unable to find her. With nightfall approaching, they realize they're lost and have no idea how to get back to civilization.
As they try to survive in the jungle, the friends begin to realize they're being stalked by something sinister. They come across various warning signs left by locals about the Chupacabra, a legendary creature known for sucking the blood of its victims. With their numbers dwindling and their survival at stake, the group must find a way to outsmart the Chupacabra and make it back to safety before it's too late.
The film is shot found footage style, adding to the tension and sense of impending doom as the friends' harrowing journey unfolds onscreen. Indigenous offers a thrilling mix of horror and suspense, taking the audience on a suspenseful ride through the lush and dangerous Panamanian jungle.