As the sisters, Natalie, Sarah, and Rachel, come together after years of estrangement, they must navigate their complicated relationships with each other and their father, who is battling a terminal illness. Old wounds are reopened and long-held resentments resurface as they struggle to find common ground and support each other through this challenging time.
Throughout the film, flashbacks reveal the sisters' tumultuous upbringing and the events that led to their fractured relationship. Natalie, the oldest sister, is a successful lawyer who feels burdened by the responsibilities of caring for their father. Sarah, the middle sister, is a struggling actress who harbors resentment toward her family for not supporting her dreams. Rachel, the youngest sister, is a free-spirited musician who has distanced herself from her family in pursuit of her own happiness.
As their father's condition deteriorates, the sisters are forced to confront their unresolved issues and come to terms with the past. They must also make difficult decisions about their father's care and ultimately, say goodbye to the man who shaped their lives in so many ways.
Through moments of heartache and humor, His Three Daughters explores the complex dynamics of family relationships and the power of forgiveness and reconciliation. As the sisters grapple with their own demons and secrets come to light, they must find a way to come together as a family and forge a new future, even as they face the loss of their beloved father.