The film delves into Dr. Hunter S. Thompson's journey from a struggling writer to a counterculture icon, exploring his groundbreaking work in journalism and fearless approach to storytelling. It examines his close relationships with famous figures such as Johnny Depp, Bill Murray, and Jimmy Carter, showcasing the impact he had on both his peers and his readers. The documentary also delves into Thompson's personal struggles with drugs, alcohol, and mental health issues, shedding light on the darker aspects of his larger-than-life persona. Through interviews with those who knew him best and rare archival footage, Gonzo offers a comprehensive portrait of a man who defied convention and forever changed the landscape of American literature.