Brigitte, the main character, is on the run from both the police and the werewolf who is hot on her heels. She is desperate to find a cure for her lycanthropy and continues to take Monkshood in hopes of keeping her transformations under control. However, her supply runs out and she is forced to turn to a drug dealer, who provides her with a mixture of chemicals that keeps her from turning into a werewolf but also leads to addiction.
After an incident with the werewolf, Brigitte is arrested and sent to a rehabilitation center for drug addicts. In the clinic, she meets Ghost, a Goth girl who has been addicted to drugs since she was a child. The two of them become friends as they try to beat their addiction and stay alive.
As Brigitte struggles with withdrawal symptoms and her lycanthropy, she starts to see the ghost of her sister, Ginger, who died in the first movie. Ginger's spirit taunts Brigitte and urges her to give in to her inner animal.
Meanwhile, the werewolf that has been following Brigitte turns out to be a man named Tyler, who is also addicted to Monkshood. As Brigitte and Ghost learn more about Tyler's past, they discover that he was infected with lycanthropy as a child and has been on a quest to find a cure ever since.
As the full moon approaches, Brigitte and Ghost must find a way to break the cycle of addiction and stop Tyler from turning into a werewolf. In the end, Brigitte is forced to make a difficult decision that could mean the difference between life and death for all of them.