Death Rider in the House of Vampires is a horror action movie set in the Wild West. The titular character, Death Rider, is a skilled gunslinger with a dark past who rides into a remote town to investigate the disappearance of his sister. Along the way, he learns of a dangerous Vampire Sanctuary where a group of bloodthirsty vampires are rumored to reside.
Desperate to find answers, Death Rider decides to infiltrate the sanctuary. However, the price of admission is steep: one female virgin. Death Rider manages to find a willing participant in the form of a tough, gun-toting cowgirl named Bernadette. Together, they enter the sanctuary, ready to face off against the deadly vampires and uncover the secrets buried within.
Once inside, Death Rider and Bernadette discover that the vampires are led by a powerful and seductive queen named Carmilla. As they delve deeper into the sanctuary's dark and twisted halls, they are confronted by a variety of monstrous creatures, each more terrifying than the last.
Despite the overwhelming odds, Death Rider and Bernadette refuse to back down. With their guns blazing and their wits sharp, they will fight their way through hordes of vampires and other supernatural beings to uncover the truth about Death Rider's sister and put an end to the reign of terror within the Vampire Sanctuary.