In the movie Bride of Chucky, Tiffany is the ex-girlfriend of Charles Lee Ray, the infamous serial killer who became trapped inside a Good Guys doll and rebranded himself as Chucky. Tiffany, who has kept the Chucky doll as a macabre keepsake, manages to revive him using a ritual that includes a vial of his blood. However, things take an unexpected turn when Tiffany herself is transformed into a doll after being killed by Chucky in a fit of rage.
Now both dolls are alive and murderous, they embark on a road trip across America, seeking a way to transfer their souls into human bodies. Along the way, they encounter various unsuspecting individuals who fall prey to their killing sprees. Among them are a teenage couple, Jesse and Jade, who become entangled in Chucky and Tiffany's murderous plot after stealing a pair of Chucky's old dolls from a police evidence locker.
As Chucky and Tiffany continue their killing spree, they begin to bicker and fight, their relationship strained by their inability to trust each other and by their opposing personalities. Chucky is still a ruthless killer, but Tiffany struggles with her newfound vulnerability as a doll. Meanwhile, Jesse and Jade flee the murder scene and try to escape Chucky and Tiffany's wrath.
In a dramatic climax, the dolls finally succeed in transferring their souls into human bodies, but their happiness is short-lived as the police arrive just in time to take them down. In their final moments, Chucky and Tiffany express their love for each other before being destroyed, leaving Jesse and Jade to make their escape and try to forget the nightmare they've been through.