In Big Business, Bette Midler and Lily Tomlin each play dual roles as the sets of twins. Midler and Tomlin play Sadie and Rose Shelton, the wealthy sisters who were born to the visiting family, and the poor sisters, Sadie and Rose Ratliff.
As the two sets of twins grow up, they each go down different paths in life. The Shelton sisters become the powerful co-owners of Moramax, a successful cosmetics company, while the Ratliff sisters struggle to make ends meet and run a small town business.
When both sets of twins arrive in New York City for a Moramax shareholders' meeting, chaos ensues as the two sets are mistaken for each other. The Ratliff sisters are taken on as the Moramax executives, leading to a series of hilarious mix-ups as they navigate the cut-throat world of high-end business while the Shelton sisters find themselves stranded in Jupiter Hollow dealing with the Ratliff family's problems.
As they navigate their new circumstances, both sets of twins begin to learn important lessons about family, love, and the true value of success. Big Business is a charming and classic comedy that showcases Midler and Tomlin's comedic talents and celebrates the power of sisterhood, no matter where you come from.