The scientific expedition is led by Dr. Jack Byron (played by Matthew Marsden), a wealthy businessman who funded the mission in hopes of making a huge profit from the discovery of the blood orchid. Accompanying him are a team of scientists and experts, including Dr. Ben Douglas (played by KaDee Strickland), Dr. Sam Rogers (played by Eugene Byrd), Gail Stern (played by Salli Richardson), and Cole Burris (played by Morris Chestnut).
As they journey deep into the Borneo jungle, they encounter a number of obstacles along the way, including rough terrain, hostile natives, and deadly animals. But it's the giant anacondas that prove to be the most dangerous adversaries, as they are fiercely territorial and will do anything to protect their home.
As the team struggles to survive in the brutal jungle environment, tensions rise among the members, particularly between Dr. Byron and the others, who begin to suspect he has a hidden agenda.
In the end, the team must work together to overcome the giant snakes and make it out of the jungle alive, all while trying to protect the valuable blood orchid from falling into the wrong hands.