As the two friends embark on their road trip from Los Angeles to San Diego, they are full of excitement and anticipation. Hannah, who was once a reality TV star, is eager to meet her high school crush, while Brooklyn, a conscious cuddling enthusiast, is excited to attend Comic Con.
However, things start to go awry as soon as they reach San Diego. Their hotel reservation falls through, and they are forced to stay in a run-down motel on the outskirts of the city. Their high school crush turns out to be a disappointment, and they find themselves wandering the streets of San Diego, looking for something to do.
As they explore the city, they encounter a series of eccentric characters, from a group of partying frat boys to a group of cosplayers. They also find themselves caught up in a series of wild and unpredictable events, including a high-speed car chase, a strip club visit, and a romantic entanglement with a local bartender.
Through it all, Hannah and Brooklyn must rely on each other to navigate the chaos of their night in San Diego. As they confront their deepest fears and vulnerabilities, they are forced to confront the true nature of their friendship and the strength of their bond.
Ultimately, 1 Night In San Diego is a hilarious and heartwarming exploration of the ups and downs of friendship, as two women discover the true meaning of loyalty, love, and adventure.